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While weight gain was not listed as a side effect from their initial clinical trials, studies have shown that people using SSRIs such as Zoloft can have an increase in body weight when taking these medications

In the NEJM 2023 phase 2 trial, the highest-dose group achieved approximately 24% mean body weight reduction at 48 weeks, exceeding results reported for both semaglutide and tirzepatide in their own trials

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